Organic anion transporting polypeptide-C mediates arsenic uptake in HEK-293 cells
نویسندگان
چکیده
منابع مشابه
Protein kinase C suppresses rat organic anion transporting polypeptide 1- and 2-mediated uptake.
Rat oatp1 (Slc21a1) and oatp2 (Slc21a5) transport many structurally unrelated endogenous and exogenous compounds across the sinusoidal membrane of hepatocytes in a sodium-independent manner. There are several potential protein kinase A (PKA) and protein kinase C (PKC) phosphorylation sites in both rat oatp1 and oatp2 proteins, suggesting that PKA and/or PKC may play a role in regulating their f...
متن کاملUptake of enalapril and expression of organic anion transporting polypeptide 1 in zonal, isolated rat hepatocytes.
Sinusoidal entry is the first obligatory process preceding intracellular drug removal in liver. Transport of the angiotensin converting enzyme inhibitor enalapril (1-750 microM with [(3)H]enalapril), a substrate of Oatp1, the sodium-independent organic anion transporting polypeptide 1 cloned from rat liver, was studied in rat hepatocytes isolated from all zones of the liver (homogeneous) and fr...
متن کاملOrganic anion transporting polypeptide 1a4 is responsible for the hepatic uptake of cardiac glycosides in mice.
Among organic anion transporting polypeptide (Oatp) family transporters expressed in the rodent liver, such as Oatp1a1, Oatp1a4, Oatp1b2, and Oatp2b1, Oatp1a4 has a unique character to recognize neutral cardiac glycosides as substrate in addition to organic anions. The relative contribution of Oatp1a4 to the substrate uptake into hepatocytes has not been clarified. In this study, we investigate...
متن کاملOrganic anion transporting polypeptide 1B transporters modulate hydroxyurea pharmacokinetics.
Hydroxyurea is currently the only FDA-approved drug that ameliorates the pathophysiology of sickle cell anemia. Unfortunately, substantial interpatient variability in the pharmacokinetics (PK) of hydroxyurea may result in variation of the drug's efficacy. However, little is known about mechanisms that modulate hydroxyurea PK. Recent in vitro studies identifying hydroxyurea as a substrate for or...
متن کاملSTRUCTURAL REQUIREMENTS OF ORGANIC ANION TRANSPORTING POLYPEPTIDE MEDIATED TRANSPORT by
The organic anion transporting polypeptides (human: OATP; other: Oatp) form a mammalian transporter superfamily that mediates the transport of structurally unrelated compounds across the cell membrane. Members in this superfamily participate in the absorption, distribution and excretion of many endogenous and exogenous substances including a number of medications and environmental toxicants. Po...
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ژورنال
عنوان ژورنال: Journal of Biomedical Science
سال: 2006
ISSN: 1021-7770,1423-0127
DOI: 10.1007/s11373-006-9071-0